منابع مشابه
High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency.
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing the sulfate group from its structure to obtain free cholesterol. CS has been reported, so far, as the sole sulfated steroid with incr...
متن کاملHigh levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency. AUTHORS
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing the sulfate group from its structure to obtain free cholesterol. CS has been reported so far as the sole sulfated steroid with increa...
متن کاملDevelopment of steroid sulfatase inhibitors.
Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast. Considerable progress has been made in the past two decades with regard to the discovery, design and development of STS inhibitors. We outline historical aspects of their deve...
متن کاملEnzymatic synthesis of steroid sulfates.
De Meio and Lewycka (1) have obtained indirect evidence that conjugation of dehydroisoandrosterone with sulfuric acid occurs in a system consisting of microsome-free supernatant fluid of rat liver, adenosine triphosphate (ATP), and magnesium and sulfate ions. They showed that, following incubation, some of the Zimmermann-positive material remains in the aqueous phase after ether extraction at p...
متن کاملTesticular steroid sulfatase. Substrate specificity and inhibition.
Kinetic studies of the cleavage of dehydroepiandrosterone-sulfate (i) and androstenediol-3-sulfate by a particulate enzyme preparation from a rat testicular microsomal fraction gave K m values of 2.04 x 10-6M for DHA-S and 0.935 x 10-6M for androstenediol-3-sulfate with identical Vma x values° Inhibition studies with equimolar concentrations of substrate and inhibitor demonstrated that 5~-andro...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Enzymology
سال: 1972
ISSN: 0005-2744
DOI: 10.1016/0005-2744(72)90239-2